Santa Barbara, CA, April 12
(Ascribe Newswire)
Cinnamon may be more than a spice -- it may have a medical application
in preventing and combating diabetes. Cinnamon may help by playing the
role of an insulin substitute in type 2 diabetes, according to cellular
and molecular studies at the University of California, Santa Barbara,
Iowa State University and the U.S. Department of Agriculture.
"Cinnamon itself has insulin-like activity and also can potentiate
the activity of insulin," said Don Graves of UCSB. "The latter
could be quite important in treating those with type 2 diabetes. Cinnamon
has a bio-active component that we believe has the potential to prevent
or overcome diabetes."
The healthful effects of cinnamon on mice with diabetes are being studied
in a joint project at the UCSB and the Sansum Diabetes Research Institute
in Santa Barbara.
The researchers have been studying the effects of cinnamon on obese
mice, which have been fed water laced with cinnamon at Sansum's lab,
according to Graves, who is running the project with Lois Jovanovic,
Sansum's research director.
When the trials are completed, 60 diabetic mice will have been studied,
sponsored by a grant to UCSB from Cottage Hospital, Santa Barbara. The
study began six months ago and final results are expected in about six
months.
"More than 170 million people worldwide suffer from diabetes,
and for many, drugs or other forms of treatment are unavailable,"
said Graves. "It may be possible that many of these people could
benefit from readily available natural products such as cinnamon."
Graves, an adjunct professor of Molecular, Cellular and Developmental
Biology, retired from Iowa State University in October 2000 and came
to UCSB the same month. He was familiar with UCSB from his days as a
visiting professor in the Department of Chemistry during the 1970s and
decided to return. He now divides his time between UCSB and the Sansum
Institute.
Using nuclear magnetic resonance and mass spectroscopy, the researchers
obtained results which allowed them to describe the chemical structure
of a molecule with "insulin-like" activity in cinnamon. Graves
and others reported earlier that this compound, a proanthocyanidin,
can affect insulin signaling in fat cells.
Richard Anderson of the U.S. Department of Agriculture, a former Graves
student and the discoverer of the insulin-like activity, recently completed
a human study with associates in Pakistan using cinnamon. Promising
results were obtained by 30 test subjects with type 2 diabetes after
only 40 days of taking cinnamon. They had a significant decrease in
blood glucose, triglycerides, LDL, and cholesterol. The researchers
hope that a human trial may begin in the US, possibly in Santa Barbara,
using cinnamon and its water-soluble extract to treat type 2 diabetes.
Type 2 diabetes is a disease in which the body develops a resistance
to insulin, thus preventing the cells from receiving the glucose that
they need to function. The work at UCSB is focused on the way cinnamon
operates at cellular and molecular levels, looking at how it works with
the cell's insulin receptor and other proteins involved in reactions
associated with the action of insulin.
Graves said that other major diseases could possibly be helped by cinnamon.
For example one prospect is pancreatic cancer, a disease in which abnormal
amounts of insulin are produced by the pancreas in response to the cancer
tumor causing insulin resistance in the cells of the body. The resistance
prevents glucose availability to the cells. Graves believes that cinnamon
might help overcome this resistance. "It's speculative but exciting,"
he said.
Recent studies have shown that insulin resistance may also be involved
in neurodegenerative diseases such as Alzheimer's, according to Graves.
A study testing the effects of the "insulin-like" component
of cinnamon on protein reactions associated with Alzheimer's disease
is planned at UCSB's Neuroscience Research Institute (NRI). Graves is
working in the NRI lab of John Lew, who studies Alzheimer's disease.
Graves calls himself a "scientific grandfather" to Lew, since
Lew's major professor, Jery Wang, was a Ph.D. student of Graves at Iowa
State University in 1961. Wang later became Lew's major professor at
the University of Calgary.